The challenge in orally disintegrating tablets (ODTs) production encompasses the compromise between\ninstantaneous disintegration and sufficient physico-mechanical properties, therefore the aim of this\nstudy was to evaluate the influence of selected disintegrants on the characteristics of ODTs\nmanufactured using novel ready-to-use excipients (Ludiflash�® or Parteck�®) by direct compression\nmethod. Effect of selected disintegrants (croscarmellose sodium, microcrystalline cellulose and four\ntypes of crospovidone) on hardness, friability, wetting time, in vitro and in vivo disintegration time,\nroughness and stability parameters has been studied. The prepared tablets were also evaluated for\nsurface morphology and pore structure. 3% w/w addition of all examined disintegrants enabled\nobtaining tablets showing physico-mechanical properties that are suitable for ODTs, but disintegration\ntimes < 30 s were observed only in formulations with crospovidones. The surface of Ludiflash�® and\nParteck�® ODTs was relatively homogenous dispersion with pores, cracks and fissures. Formulations\nwith Ludiflash�® showed both less porous textures with low specific surface area (BET values up to 0.77\nm2/g) and shorter wetting and disintegration times. The optimized formulation containing superfine\ncrospovidone and Ludiflash�® (L2) or Parteck�® (P2) was found to be stable, had a pleasant mouth feel\nand disintegrated in the oral cavity within only 10 and 26 s, respectively.
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